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A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study)

Identificadores del recurso

Forcano Gamazo L, Soldevila-Domenech N, Boronat A, Sánchez-Benavides GA, Puig-Pijoan A, Lorenzo T, et al. A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study). J Prev Alzheimers Dis. 2025 Sep;12(8):100271. DOI: 10.1016/j.tjpad.2025.100271

2426-0266

https://hdl.handle.net/20.500.12367/3232

10.1016/j.tjpad.2025.100271

Procedencia

(Repositori Digital del TecnoCampus)

Ficha

Título:: A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study)
Tema:: Multimodal lifestyle intervention; Prevention; APOE-ɛ4; Epigallocatechin-3-gallate; Subjective Cognitive Decline; Randomized Controlled Trial
Descripción:: Background: The potential of dietary compounds to enhance the effects of multimodal lifestyle interventions (MLIs) on cognition in individuals at high risk of cognitive impairment remains unclear. Objectives: To assess whether the addition of a green tea extract enriched with epigallocatechin-3-gallate (EGCG) enhances the effects of an MLI. Design: Double-blind, randomized, two-arm, and placebo-controlled trial. Exploratory comparisons were made with a non-randomized group (NRG) receiving healthy lifestyle recommendations. Setting: Population-based study conducted in Barcelona, Spain. [...]; info:eu-repo/semantics/publishedVersion
Idioma:: English
Relación:: The Journal of Prevention of Alzheimer's Disease. 2025 Sep;12(8):100271
Autor/Productor:: Forcano Gamazo, Laura; Soldevila-Domenech, Natalia; Boronat, Anna; Sánchez-Benavides, Gonzalo Andrés; Puig-Pijoan, Albert; Lorenzo, Thais; Aldea-Perona, Ana; Suárez-Calvet, Marc; Cuenca Royo, Aida; Gispert, Juan Domingo; Gomis-Gonzalez, Maria; Minguillon, Carolina; Diaz-Pellicer, Patricia; Fauria, Karine; Piera, Iris; Langohr, Klaus; Dierssen, Mara; Pizarro Lozano, Nieves; Mur, Esther; Grau-Rivera, Oriol; de la Torre, Rafael
Editor:: Springer Nature
Derechos:: Attribution 4.0 International; http://creativecommons.org/licenses/by/4.0/; info:eu-repo/semantics/openAccess
Fecha:: 2026-06-01T12:20:35Z; 2025-09
Tipo de recurso:: info:eu-repo/semantics/article
Formato:: 12 p.; application/pdf

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1. < dc:title > A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study) </ dc:title >
2. < dc:creator > Forcano Gamazo, Laura </ dc:creator >
3. < dc:creator > Soldevila-Domenech, Natalia </ dc:creator >
4. < dc:creator > Boronat, Anna </ dc:creator >
5. < dc:creator > Sánchez-Benavides, Gonzalo Andrés </ dc:creator >
6. < dc:creator > Puig-Pijoan, Albert </ dc:creator >
7. < dc:creator > Lorenzo, Thais </ dc:creator >
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9. < dc:creator > Suárez-Calvet, Marc </ dc:creator >
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11. < dc:creator > Gispert, Juan Domingo </ dc:creator >
12. < dc:creator > Gomis-Gonzalez, Maria </ dc:creator >
13. < dc:creator > Minguillon, Carolina </ dc:creator >
14. < dc:creator > Diaz-Pellicer, Patricia </ dc:creator >
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16. < dc:creator > Piera, Iris </ dc:creator >
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18. < dc:creator > Dierssen, Mara </ dc:creator >
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22. < dc:creator > de la Torre, Rafael </ dc:creator >
23. < dc:subject > Multimodal lifestyle intervention </ dc:subject >
24. < dc:subject > Prevention </ dc:subject >
25. < dc:subject > APOE-ɛ4 </ dc:subject >
26. < dc:subject > Epigallocatechin-3-gallate </ dc:subject >
27. < dc:subject > Subjective Cognitive Decline </ dc:subject >
28. < dc:subject > Randomized Controlled Trial </ dc:subject >
29. < dc:description > Background: The potential of dietary compounds to enhance the effects of multimodal lifestyle interventions (MLIs) on cognition in individuals at high risk of cognitive impairment remains unclear. Objectives: To assess whether the addition of a green tea extract enriched with epigallocatechin-3-gallate (EGCG) enhances the effects of an MLI. Design: Double-blind, randomized, two-arm, and placebo-controlled trial. Exploratory comparisons were made with a non-randomized group (NRG) receiving healthy lifestyle recommendations. Setting: Population-based study conducted in Barcelona, Spain. [...] </ dc:description >
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39. < dc:language > eng </ dc:language >
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2. < creator > Forcano Gamazo, Laura </ creator >
3. < creator > Soldevila-Domenech, Natalia </ creator >
4. < creator > Boronat, Anna </ creator >
5. < creator > Sánchez-Benavides, Gonzalo Andrés </ creator >
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23. < dc:subject > Multimodal lifestyle intervention </ dc:subject >
24. < dc:subject > Prevention </ dc:subject >
25. < dc:subject > APOE-ɛ4 </ dc:subject >
26. < dc:subject > Epigallocatechin-3-gallate </ dc:subject >
27. < dc:subject > Subjective Cognitive Decline </ dc:subject >
28. < dc:subject > Randomized Controlled Trial </ dc:subject >
29. < dc:description > Background: The potential of dietary compounds to enhance the effects of multimodal lifestyle interventions (MLIs) on cognition in individuals at high risk of cognitive impairment remains unclear. Objectives: To assess whether the addition of a green tea extract enriched with epigallocatechin-3-gallate (EGCG) enhances the effects of an MLI. Design: Double-blind, randomized, two-arm, and placebo-controlled trial. Exploratory comparisons were made with a non-randomized group (NRG) receiving healthy lifestyle recommendations. Setting: Population-based study conducted in Barcelona, Spain. [...] </ dc:description >
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33. < dc:date > 2025-09 </ dc:date >
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36. < dcrecercat:subject > Epigallocatechin-3-gallate </ dcrecercat:subject >
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39. < dcrecercat:descriptionabstract > Background: The potential of dietary compounds to enhance the effects of multimodal lifestyle interventions (MLIs) on cognition in individuals at high risk of cognitive impairment remains unclear. Objectives: To assess whether the addition of a green tea extract enriched with epigallocatechin-3-gallate (EGCG) enhances the effects of an MLI. Design: Double-blind, randomized, two-arm, and placebo-controlled trial. Exploratory comparisons were made with a non-randomized group (NRG) receiving healthy lifestyle recommendations. Setting: Population-based study conducted in Barcelona, Spain. [...] </ dcrecercat:descriptionabstract >
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        < field name =" value " > Background: The potential of dietary compounds to enhance the effects of multimodal lifestyle interventions (MLIs) on cognition in individuals at high risk of cognitive impairment remains unclear. Objectives: To assess whether the addition of a green tea extract enriched with epigallocatechin-3-gallate (EGCG) enhances the effects of an MLI. Design: Double-blind, randomized, two-arm, and placebo-controlled trial. Exploratory comparisons were made with a non-randomized group (NRG) receiving healthy lifestyle recommendations. Setting: Population-based study conducted in Barcelona, Spain. [...] </ field >
        
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