<?xml version="1.0" encoding="UTF-8" ?>
< oai_dc:dc schemaLocation =" http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd " >
< dc:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ dc:title >
< dc:creator > Riesco-Llach, Gerard </ dc:creator >
< dc:creator > Planas i Grabuleda, Marta </ dc:creator >
< dc:creator > Feliu Soley, Lídia </ dc:creator >
< dc:creator > Joule, John A. </ dc:creator >
< dc:subject > Compostos bioactius -- Síntesi </ dc:subject >
< dc:subject > Bioactive compounds -- Synthesis </ dc:subject >
< dc:subject > Pirazines -- Síntesi </ dc:subject >
< dc:subject > Pyrazines -- Synthesis </ dc:subject >
< dc:description > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ dc:description >
< dc:description > G. R.-L. is recipient of a predoctoral fellowship from the University of Girona (IFUdG2020) </ dc:description >
< dc:date > 2023-01-04 </ dc:date >
< dc:type > info:eu-repo/semantics/article </ dc:type >
< dc:type > info:eu-repo/semantics/publishedVersion </ dc:type >
< dc:type > peer-reviewed </ dc:type >
< dc:identifier > http://hdl.handle.net/10256/22462 </ dc:identifier >
< dc:relation > info:eu-repo/semantics/altIdentifier/doi/10.1039/D2RA07227K </ dc:relation >
< dc:relation > info:eu-repo/semantics/altIdentifier/eissn/2046-2069 </ dc:relation >
< dc:language > eng </ dc:language >
< dc:source > RSC Advances, 2023,vol. 13, p. 1162-1184 </ dc:source >
< dc:source > Articles publicats (D-Q) </ dc:source >
< dc:rights > Attribution-NonCommercial 4.0 International </ dc:rights >
< dc:rights > http://creativecommons.org/licenses/by-nc/4.0/ </ dc:rights >
< dc:rights > info:eu-repo/semantics/openAccess </ dc:rights >
< dc:format > application/pdf </ dc:format >
< dc:publisher > Royal Society of Chemistry (RSC) </ dc:publisher >
</ oai_dc:dc >
<?xml version="1.0" encoding="UTF-8" ?>
< d:DIDL schemaLocation =" urn:mpeg:mpeg21:2002:02-DIDL-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/did/didl.xsd " >
< d:DIDLInfo >
< dcterms:created schemaLocation =" http://purl.org/dc/terms/ http://dublincore.org/schemas/xmls/qdc/dcterms.xsd " > 2023-01-17T14:10:46Z </ dcterms:created >
</ d:DIDLInfo >
< d:Item id =" hdl_10256_22462 " >
< d:Descriptor >
< d:Statement mimeType =" application/xml; charset=utf-8 " >
< dii:Identifier schemaLocation =" urn:mpeg:mpeg21:2002:01-DII-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/dii/dii.xsd " > urn:hdl:10256/22462 </ dii:Identifier >
</ d:Statement >
</ d:Descriptor >
< d:Descriptor >
< d:Statement mimeType =" application/xml; charset=utf-8 " >
< oai_dc:dc schemaLocation =" http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd " >
< dc:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ dc:title >
< dc:creator > Riesco-Llach, Gerard </ dc:creator >
< dc:creator > Planas i Grabuleda, Marta </ dc:creator >
< dc:creator > Feliu Soley, Lídia </ dc:creator >
< dc:creator > Joule, John A. </ dc:creator >
< dc:subject > Compostos bioactius -- Síntesi </ dc:subject >
< dc:subject > Bioactive compounds -- Synthesis </ dc:subject >
< dc:subject > Pirazines -- Síntesi </ dc:subject >
< dc:subject > Pyrazines -- Synthesis </ dc:subject >
< dc:description > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ dc:description >
< dc:date > 2023-01-17T14:10:46Z </ dc:date >
< dc:date > 2023-01-17T14:10:46Z </ dc:date >
< dc:date > 2023-01-04 </ dc:date >
< dc:type > info:eu-repo/semantics/article </ dc:type >
< dc:identifier > http://hdl.handle.net/10256/22462 </ dc:identifier >
< dc:identifier > https://doi.org/10.1039/D2RA07227K </ dc:identifier >
< dc:identifier > 035933 </ dc:identifier >
< dc:identifier > 2046-2069 </ dc:identifier >
< dc:language > eng </ dc:language >
< dc:relation > Reproducció digital del document publicat a: https://doi.org/10.1039/D2RA07227K </ dc:relation >
< dc:relation > RSC Advances, 2023,vol. 13, p. 1162-1184 </ dc:relation >
< dc:relation > Articles publicats (D-Q) </ dc:relation >
< dc:rights > http://creativecommons.org/licenses/by-nc/4.0/ </ dc:rights >
< dc:rights > info:eu-repo/semantics/openAccess </ dc:rights >
< dc:rights > Attribution-NonCommercial 4.0 International </ dc:rights >
< dc:publisher > Royal Society of Chemistry (RSC) </ dc:publisher >
</ oai_dc:dc >
</ d:Statement >
</ d:Descriptor >
< d:Component id =" 10256_22462_1 " >
</ d:Component >
</ d:Item >
</ d:DIDL >
<?xml version="1.0" encoding="UTF-8" ?>
< dim:dim schemaLocation =" http://www.dspace.org/xmlns/dspace/dim http://www.dspace.org/schema/dim.xsd " >
< dim:field element =" contributor " mdschema =" dc " qualifier =" author " > Riesco-Llach, Gerard </ dim:field >
< dim:field element =" contributor " mdschema =" dc " qualifier =" author " > Planas i Grabuleda, Marta </ dim:field >
< dim:field element =" contributor " mdschema =" dc " qualifier =" author " > Feliu Soley, Lídia </ dim:field >
< dim:field element =" contributor " mdschema =" dc " qualifier =" author " > Joule, John A. </ dim:field >
< dim:field element =" date " mdschema =" dc " qualifier =" accessioned " > 2023-01-17T14:10:46Z </ dim:field >
< dim:field element =" date " mdschema =" dc " qualifier =" available " > 2023-01-17T14:10:46Z </ dim:field >
< dim:field element =" date " mdschema =" dc " qualifier =" issued " > 2023-01-04 </ dim:field >
< dim:field element =" identifier " mdschema =" dc " qualifier =" uri " > http://hdl.handle.net/10256/22462 </ dim:field >
< dim:field element =" identifier " mdschema =" dc " qualifier =" doi " > https://doi.org/10.1039/D2RA07227K </ dim:field >
< dim:field element =" identifier " mdschema =" dc " qualifier =" idgrec " > 035933 </ dim:field >
< dim:field element =" identifier " mdschema =" dc " qualifier =" eissn " > 2046-2069 </ dim:field >
< dim:field element =" description " lang =" cat " mdschema =" dc " qualifier =" abstract " > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ dim:field >
< dim:field element =" description " lang =" en " mdschema =" dc " qualifier =" provenance " > Submitted by Claudia Plana (claudia.plana@udg.edu) on 2023-01-17T14:10:46Z No. of bitstreams: 2 license_rdf: 914 bytes, checksum: 24013099e9e6abb1575dc6ce0855efd5 (MD5) d2ra07227k.pdf: 2762086 bytes, checksum: d7dfebe5a2889455a9d92e394bf1e6f4 (MD5) </ dim:field >
< dim:field element =" description " lang =" en " mdschema =" dc " qualifier =" provenance " > Made available in DSpace on 2023-01-17T14:10:46Z (GMT). No. of bitstreams: 2 license_rdf: 914 bytes, checksum: 24013099e9e6abb1575dc6ce0855efd5 (MD5) d2ra07227k.pdf: 2762086 bytes, checksum: d7dfebe5a2889455a9d92e394bf1e6f4 (MD5) Previous issue date: 2023-01-04 </ dim:field >
< dim:field element =" description " lang =" cat " mdschema =" dc " qualifier =" sponsorship " > G. R.-L. is recipient of a predoctoral fellowship from the University of Girona (IFUdG2020) </ dim:field >
< dim:field element =" format " lang =" cat " mdschema =" dc " qualifier =" mimetype " > application/pdf </ dim:field >
< dim:field element =" language " lang =" cat " mdschema =" dc " qualifier =" iso " > eng </ dim:field >
< dim:field element =" publisher " lang =" cat " mdschema =" dc " > Royal Society of Chemistry (RSC) </ dim:field >
< dim:field element =" relation " lang =" cat " mdschema =" dc " qualifier =" isformatof " > Reproducció digital del document publicat a: https://doi.org/10.1039/D2RA07227K </ dim:field >
< dim:field element =" relation " lang =" cat " mdschema =" dc " qualifier =" ispartof " > RSC Advances, 2023,vol. 13, p. 1162-1184 </ dim:field >
< dim:field element =" relation " lang =" cat " mdschema =" dc " qualifier =" ispartofseries " > Articles publicats (D-Q) </ dim:field >
< dim:field element =" rights " lang =" * " mdschema =" dc " > Attribution-NonCommercial 4.0 International </ dim:field >
< dim:field element =" rights " lang =" * " mdschema =" dc " qualifier =" uri " > http://creativecommons.org/licenses/by-nc/4.0/ </ dim:field >
< dim:field element =" rights " lang =" cat " mdschema =" dc " qualifier =" accessRights " > info:eu-repo/semantics/openAccess </ dim:field >
< dim:field element =" subject " lang =" cat " mdschema =" dc " > Compostos bioactius -- Síntesi </ dim:field >
< dim:field element =" subject " lang =" cat " mdschema =" dc " > Bioactive compounds -- Synthesis </ dim:field >
< dim:field element =" subject " lang =" cat " mdschema =" dc " > Pirazines -- Síntesi </ dim:field >
< dim:field element =" subject " lang =" cat " mdschema =" dc " > Pyrazines -- Synthesis </ dim:field >
< dim:field element =" title " lang =" cat " mdschema =" dc " > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ dim:field >
< dim:field element =" type " lang =" cat " mdschema =" dc " > info:eu-repo/semantics/article </ dim:field >
< dim:field element =" type " lang =" cat " mdschema =" dc " qualifier =" version " > info:eu-repo/semantics/publishedVersion </ dim:field >
< dim:field element =" type " lang =" cat " mdschema =" dc " qualifier =" peerreviewed " > peer-reviewed </ dim:field >
</ dim:dim >
<?xml version="1.0" encoding="UTF-8" ?>
< rdf:RDF schemaLocation =" http://www.w3.org/1999/02/22-rdf-syntax-ns# http://www.europeana.eu/schemas/edm/EDM.xsd " >
< edm:ProvidedCHO about =" https://catalonica.bnc.cat/catalonicahub/lod/oai:dugi-doc.udg.edu:10256_--_22462#ent0 " >
< dc:creator > Riesco-Llach, Gerard </ dc:creator >
< dc:creator > Planas i Grabuleda, Marta </ dc:creator >
< dc:creator > Feliu Soley, Lídia </ dc:creator >
< dc:creator > Joule, John A. </ dc:creator >
< dc:date > 2023-01-04 </ dc:date >
< dc:description > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ dc:description >
< dc:description > G. R.-L. is recipient of a predoctoral fellowship from the University of Girona (IFUdG2020) </ dc:description >
< dc:identifier > http://hdl.handle.net/10256/22462 </ dc:identifier >
< dc:language > eng </ dc:language >
< dc:publisher > Royal Society of Chemistry (RSC) </ dc:publisher >
< dc:relation > info:eu-repo/semantics/altIdentifier/doi/10.1039/D2RA07227K </ dc:relation >
< dc:relation > info:eu-repo/semantics/altIdentifier/eissn/2046-2069 </ dc:relation >
< dc:rights > Attribution-NonCommercial 4.0 International </ dc:rights >
< dc:rights > http://creativecommons.org/licenses/by-nc/4.0/ </ dc:rights >
< dc:rights > info:eu-repo/semantics/openAccess </ dc:rights >
< dc:source > RSC Advances, 2023,vol. 13, p. 1162-1184 </ dc:source >
< dc:source > Articles publicats (D-Q) </ dc:source >
< dc:subject > Compostos bioactius -- Síntesi </ dc:subject >
< dc:subject > Bioactive compounds -- Synthesis </ dc:subject >
< dc:subject > Pirazines -- Síntesi </ dc:subject >
< dc:subject > Pyrazines -- Synthesis </ dc:subject >
< dc:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ dc:title >
< dc:type > info:eu-repo/semantics/article </ dc:type >
< dc:type > info:eu-repo/semantics/publishedVersion </ dc:type >
< dc:type > peer-reviewed </ dc:type >
< edm:type > TEXT </ edm:type >
</ edm:ProvidedCHO >
< ore:Aggregation about =" https://catalonica.bnc.cat/catalonicahub/lod/oai:dugi-doc.udg.edu:10256_--_22462#ent1 " >
< edm:dataProvider > DUGiDocs. Recerca </ edm:dataProvider >
< edm:provider > Catalònica </ edm:provider >
</ ore:Aggregation >
</ rdf:RDF >
<?xml version="1.0" encoding="UTF-8" ?>
< thesis schemaLocation =" http://www.ndltd.org/standards/metadata/etdms/1.0/ http://www.ndltd.org/standards/metadata/etdms/1.0/etdms.xsd " >
< title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ title >
< creator > Riesco-Llach, Gerard </ creator >
< creator > Planas i Grabuleda, Marta </ creator >
< creator > Feliu Soley, Lídia </ creator >
< creator > Joule, John A. </ creator >
< subject > Compostos bioactius -- Síntesi </ subject >
< subject > Bioactive compounds -- Synthesis </ subject >
< subject > Pirazines -- Síntesi </ subject >
< subject > Pyrazines -- Synthesis </ subject >
< description > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ description >
< date > 2023-01-17 </ date >
< date > 2023-01-17 </ date >
< date > 2023-01-04 </ date >
< type > info:eu-repo/semantics/article </ type >
< identifier > http://hdl.handle.net/10256/22462 </ identifier >
< identifier > https://doi.org/10.1039/D2RA07227K </ identifier >
< identifier > 035933 </ identifier >
< identifier > 2046-2069 </ identifier >
< language > eng </ language >
< relation > Reproducció digital del document publicat a: https://doi.org/10.1039/D2RA07227K </ relation >
< relation > RSC Advances, 2023,vol. 13, p. 1162-1184 </ relation >
< relation > Articles publicats (D-Q) </ relation >
< rights > http://creativecommons.org/licenses/by-nc/4.0/ </ rights >
< rights > info:eu-repo/semantics/openAccess </ rights >
< rights > Attribution-NonCommercial 4.0 International </ rights >
< publisher > Royal Society of Chemistry (RSC) </ publisher >
</ thesis >
<?xml version="1.0" encoding="UTF-8" ?>
< record schemaLocation =" http://www.loc.gov/MARC21/slim http://www.loc.gov/standards/marcxml/schema/MARC21slim.xsd " >
< leader > 00925njm 22002777a 4500 </ leader >
< datafield ind1 =" " ind2 =" " tag =" 042 " >
< subfield code =" a " > dc </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 720 " >
< subfield code =" a " > Riesco-Llach, Gerard </ subfield >
< subfield code =" e " > author </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 720 " >
< subfield code =" a " > Planas i Grabuleda, Marta </ subfield >
< subfield code =" e " > author </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 720 " >
< subfield code =" a " > Feliu Soley, Lídia </ subfield >
< subfield code =" e " > author </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 720 " >
< subfield code =" a " > Joule, John A. </ subfield >
< subfield code =" e " > author </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 260 " >
< subfield code =" c " > 2023-01-04 </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 520 " >
< subfield code =" a " > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ subfield >
</ datafield >
< datafield ind1 =" 8 " ind2 =" " tag =" 024 " >
< subfield code =" a " > http://hdl.handle.net/10256/22462 </ subfield >
</ datafield >
< datafield ind1 =" 8 " ind2 =" " tag =" 024 " >
< subfield code =" a " > https://doi.org/10.1039/D2RA07227K </ subfield >
</ datafield >
< datafield ind1 =" 8 " ind2 =" " tag =" 024 " >
< subfield code =" a " > 035933 </ subfield >
</ datafield >
< datafield ind1 =" 8 " ind2 =" " tag =" 024 " >
< subfield code =" a " > 2046-2069 </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 653 " >
< subfield code =" a " > Compostos bioactius -- Síntesi </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 653 " >
< subfield code =" a " > Bioactive compounds -- Synthesis </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 653 " >
< subfield code =" a " > Pirazines -- Síntesi </ subfield >
</ datafield >
< datafield ind1 =" " ind2 =" " tag =" 653 " >
< subfield code =" a " > Pyrazines -- Synthesis </ subfield >
</ datafield >
< datafield ind1 =" 0 " ind2 =" 0 " tag =" 245 " >
< subfield code =" a " > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ subfield >
</ datafield >
</ record >
<?xml version="1.0" encoding="UTF-8" ?>
< mets ID =" DSpace_ITEM_10256-22462 " OBJID =" hdl:10256/22462 " PROFILE =" DSpace METS SIP Profile 1.0 " TYPE =" DSpace ITEM " schemaLocation =" http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd " >
< metsHdr CREATEDATE =" 2023-05-21T18:44:53Z " >
< agent ROLE =" CUSTODIAN " TYPE =" ORGANIZATION " >
< name > DUGiDocs </ name >
</ agent >
</ metsHdr >
< dmdSec ID =" DMD_10256_22462 " >
< mdWrap MDTYPE =" MODS " >
< xmlData schemaLocation =" http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd " >
< mods:mods schemaLocation =" http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd " >
< mods:name >
< mods:role >
< mods:roleTerm type =" text " > author </ mods:roleTerm >
</ mods:role >
< mods:namePart > Riesco-Llach, Gerard </ mods:namePart >
</ mods:name >
< mods:name >
< mods:role >
< mods:roleTerm type =" text " > author </ mods:roleTerm >
</ mods:role >
< mods:namePart > Planas i Grabuleda, Marta </ mods:namePart >
</ mods:name >
< mods:name >
< mods:role >
< mods:roleTerm type =" text " > author </ mods:roleTerm >
</ mods:role >
< mods:namePart > Feliu Soley, Lídia </ mods:namePart >
</ mods:name >
< mods:name >
< mods:role >
< mods:roleTerm type =" text " > author </ mods:roleTerm >
</ mods:role >
< mods:namePart > Joule, John A. </ mods:namePart >
</ mods:name >
< mods:extension >
< mods:dateAccessioned encoding =" iso8601 " > 2023-01-17T14:10:46Z </ mods:dateAccessioned >
</ mods:extension >
< mods:extension >
< mods:dateAvailable encoding =" iso8601 " > 2023-01-17T14:10:46Z </ mods:dateAvailable >
</ mods:extension >
< mods:originInfo >
< mods:dateIssued encoding =" iso8601 " > 2023-01-04 </ mods:dateIssued >
</ mods:originInfo >
< mods:identifier type =" uri " > http://hdl.handle.net/10256/22462 </ mods:identifier >
< mods:identifier type =" doi " > https://doi.org/10.1039/D2RA07227K </ mods:identifier >
< mods:identifier type =" idgrec " > 035933 </ mods:identifier >
< mods:identifier type =" eissn " > 2046-2069 </ mods:identifier >
< mods:abstract > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ mods:abstract >
< mods:language >
< mods:languageTerm authority =" rfc3066 " > eng </ mods:languageTerm >
</ mods:language >
< mods:accessCondition type =" useAndReproduction " > Attribution-NonCommercial 4.0 International </ mods:accessCondition >
< mods:subject >
< mods:topic > Compostos bioactius -- Síntesi </ mods:topic >
</ mods:subject >
< mods:subject >
< mods:topic > Bioactive compounds -- Synthesis </ mods:topic >
</ mods:subject >
< mods:subject >
< mods:topic > Pirazines -- Síntesi </ mods:topic >
</ mods:subject >
< mods:subject >
< mods:topic > Pyrazines -- Synthesis </ mods:topic >
</ mods:subject >
< mods:titleInfo >
< mods:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ mods:title >
</ mods:titleInfo >
< mods:genre > info:eu-repo/semantics/article </ mods:genre >
</ mods:mods >
</ xmlData >
</ mdWrap >
</ dmdSec >
< amdSec ID =" TMD_10256_22462 " >
< rightsMD ID =" RIG_10256_22462 " >
< mdWrap MDTYPE =" OTHER " MIMETYPE =" text/plain " OTHERMDTYPE =" DSpaceDepositLicense " >
< binData > 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 </ binData >
</ mdWrap >
</ rightsMD >
</ amdSec >
< amdSec ID =" FO_10256_22462_1 " >
< techMD ID =" TECH_O_10256_22462_1 " >
< mdWrap MDTYPE =" PREMIS " >
< xmlData schemaLocation =" http://www.loc.gov/standards/premis http://www.loc.gov/standards/premis/PREMIS-v1-0.xsd " >
< premis:premis >
< premis:object >
< premis:objectIdentifier >
< premis:objectIdentifierType > URL </ premis:objectIdentifierType >
< premis:objectIdentifierValue > https://dugi-doc.udg.edu/bitstream/10256/22462/1/d2ra07227k.pdf </ premis:objectIdentifierValue >
</ premis:objectIdentifier >
< premis:objectCategory > File </ premis:objectCategory >
< premis:objectCharacteristics >
< premis:fixity >
< premis:messageDigestAlgorithm > MD5 </ premis:messageDigestAlgorithm >
< premis:messageDigest > d7dfebe5a2889455a9d92e394bf1e6f4 </ premis:messageDigest >
</ premis:fixity >
< premis:size > 2762086 </ premis:size >
< premis:format >
< premis:formatDesignation >
< premis:formatName > application/pdf </ premis:formatName >
</ premis:formatDesignation >
</ premis:format >
</ premis:objectCharacteristics >
< premis:originalName > d2ra07227k.pdf </ premis:originalName >
</ premis:object >
</ premis:premis >
</ xmlData >
</ mdWrap >
</ techMD >
</ amdSec >
< fileSec >
< fileGrp USE =" ORIGINAL " >
< file ADMID =" FO_10256_22462_1 " CHECKSUM =" d7dfebe5a2889455a9d92e394bf1e6f4 " CHECKSUMTYPE =" MD5 " GROUPID =" GROUP_BITSTREAM_10256_22462_1 " ID =" BITSTREAM_ORIGINAL_10256_22462_1 " MIMETYPE =" application/pdf " SEQ =" 1 " SIZE =" 2762086 " >
</ file >
</ fileGrp >
</ fileSec >
< structMap LABEL =" DSpace Object " TYPE =" LOGICAL " >
< div ADMID =" DMD_10256_22462 " TYPE =" DSpace Object Contents " >
< div TYPE =" DSpace BITSTREAM " >
</ div >
</ div >
</ structMap >
</ mets >
<?xml version="1.0" encoding="UTF-8" ?>
< mods:mods schemaLocation =" http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd " >
< mods:name >
< mods:namePart > Riesco-Llach, Gerard </ mods:namePart >
</ mods:name >
< mods:name >
< mods:namePart > Planas i Grabuleda, Marta </ mods:namePart >
</ mods:name >
< mods:name >
< mods:namePart > Feliu Soley, Lídia </ mods:namePart >
</ mods:name >
< mods:name >
< mods:namePart > Joule, John A. </ mods:namePart >
</ mods:name >
< mods:extension >
< mods:dateAvailable encoding =" iso8601 " > 2023-01-17T14:10:46Z </ mods:dateAvailable >
</ mods:extension >
< mods:extension >
< mods:dateAccessioned encoding =" iso8601 " > 2023-01-17T14:10:46Z </ mods:dateAccessioned >
</ mods:extension >
< mods:originInfo >
< mods:dateIssued encoding =" iso8601 " > 2023-01-04 </ mods:dateIssued >
</ mods:originInfo >
< mods:identifier type =" uri " > http://hdl.handle.net/10256/22462 </ mods:identifier >
< mods:identifier type =" doi " > https://doi.org/10.1039/D2RA07227K </ mods:identifier >
< mods:identifier type =" idgrec " > 035933 </ mods:identifier >
< mods:identifier type =" eissn " > 2046-2069 </ mods:identifier >
< mods:abstract > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ mods:abstract >
< mods:language >
< mods:languageTerm > eng </ mods:languageTerm >
</ mods:language >
< mods:accessCondition type =" useAndReproduction " > http://creativecommons.org/licenses/by-nc/4.0/ </ mods:accessCondition >
< mods:accessCondition type =" useAndReproduction " > info:eu-repo/semantics/openAccess </ mods:accessCondition >
< mods:accessCondition type =" useAndReproduction " > Attribution-NonCommercial 4.0 International </ mods:accessCondition >
< mods:subject >
< mods:topic > Compostos bioactius -- Síntesi </ mods:topic >
</ mods:subject >
< mods:subject >
< mods:topic > Bioactive compounds -- Synthesis </ mods:topic >
</ mods:subject >
< mods:subject >
< mods:topic > Pirazines -- Síntesi </ mods:topic >
</ mods:subject >
< mods:subject >
< mods:topic > Pyrazines -- Synthesis </ mods:topic >
</ mods:subject >
< mods:titleInfo >
< mods:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ mods:title >
</ mods:titleInfo >
< mods:genre > info:eu-repo/semantics/article </ mods:genre >
</ mods:mods >
<?xml version="1.0" encoding="UTF-8" ?>
< datacite:resource schemaLocation =" http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4-2/metadata.xsd " >
< datacite:identifier identifierType =" Handle " > http://hdl.handle.net/10256/22462 </ datacite:identifier >
< datacite:titles >
< datacite:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ datacite:title >
</ datacite:titles >
< datacite:creators >
< datacite:creator >
< datacite:creatorName > Riesco-Llach, Gerard </ datacite:creatorName >
< datacite:nameIdentifier nameIdentifierScheme =" ORCID " schemeURI =" http://orcid.org/ " > 0000-0002-9869-7488 </ datacite:nameIdentifier >
</ datacite:creator >
< datacite:creator >
< datacite:creatorName > Planas i Grabuleda, Marta </ datacite:creatorName >
< datacite:nameIdentifier nameIdentifierScheme =" ORCID " schemeURI =" http://orcid.org/ " > 0000-0003-4988-4970 </ datacite:nameIdentifier >
</ datacite:creator >
< datacite:creator >
< datacite:creatorName > Feliu Soley, Lídia </ datacite:creatorName >
< datacite:nameIdentifier nameIdentifierScheme =" ORCID " schemeURI =" http://orcid.org/ " > 0000-0001-9792-6106 </ datacite:nameIdentifier >
</ datacite:creator >
< datacite:creator >
< datacite:creatorName > Joule, John A. </ datacite:creatorName >
</ datacite:creator >
</ datacite:creators >
< datacite:subjects >
< datacite:subject > Compostos bioactius -- Síntesi </ datacite:subject >
< datacite:subject > Bioactive compounds -- Synthesis </ datacite:subject >
< datacite:subject > Pirazines -- Síntesi </ datacite:subject >
< datacite:subject > Pyrazines -- Synthesis </ datacite:subject >
</ datacite:subjects >
< datacite:descriptions >
< datacite:description descriptionType =" Abstract " > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ datacite:description >
</ datacite:descriptions >
< datacite:dates >
< datacite:date dateType =" Issued " > 2023-01-04 </ datacite:date >
</ datacite:dates >
< datacite:publicationYear > 2023 </ datacite:publicationYear >
< datacite:languages >
< datacite:language > eng </ datacite:language >
</ datacite:languages >
< datacite:relatedIdentifiers >
< datacite:relatedIdentifier relatedIdentifierType =" DOI " relationType =" IsSupplementTo " > https://doi.org/10.1039/D2RA07227K </ datacite:relatedIdentifier >
< datacite:relatedIdentifier relatedIdentifierType =" URL " relationType =" IsSupplementTo " > 035933 </ datacite:relatedIdentifier >
< datacite:relatedIdentifier relatedIdentifierType =" URL " relationType =" IsSupplementTo " > 2046-2069 </ datacite:relatedIdentifier >
</ datacite:relatedIdentifiers >
< datacite:rightsList >
< datacite:rights > Attribution-NonCommercial 4.0 International </ datacite:rights >
< datacite:rights rightsURI =" http://creativecommons.org/licenses/by-nc/4.0/ " > http://creativecommons.org/licenses/by-nc/4.0/ </ datacite:rights >
< datacite:rights rightsURI =" info:eu-repo/semantics/openAccess " > info:eu-repo/semantics/openAccess </ datacite:rights >
</ datacite:rightsList >
< datacite:formats >
< datacite:format > application/pdf </ datacite:format >
</ datacite:formats >
< datacite:publisher > Royal Society of Chemistry (RSC) </ datacite:publisher >
</ datacite:resource >
<?xml version="1.0" encoding="UTF-8" ?>
< atom:entry schemaLocation =" http://www.w3.org/2005/Atom http://www.kbcafe.com/rss/atom.xsd.xml " >
< atom:id > http://hdl.handle.net/10256/22462/ore.xml </ atom:id >
< atom:published > 2023-01-17T14:10:46Z </ atom:published >
< atom:updated > 2023-01-17T14:10:46Z </ atom:updated >
< atom:source >
< atom:generator > DUGiDocs </ atom:generator >
</ atom:source >
< atom:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ atom:title >
< atom:author >
< atom:name > Riesco-Llach, Gerard </ atom:name >
</ atom:author >
< atom:author >
< atom:name > Planas i Grabuleda, Marta </ atom:name >
</ atom:author >
< atom:author >
< atom:name > Feliu Soley, Lídia </ atom:name >
</ atom:author >
< atom:author >
< atom:name > Joule, John A. </ atom:name >
</ atom:author >
< oreatom:triples >
< rdf:Description about =" http://hdl.handle.net/10256/22462/ore.xml#atom " >
< dcterms:modified > 2023-01-17T14:10:46Z </ dcterms:modified >
</ rdf:Description >
< rdf:Description about =" https://dugi-doc.udg.edu/bitstream/10256/22462/3/license.txt " >
< dcterms:description > LICENSE </ dcterms:description >
</ rdf:Description >
< rdf:Description about =" https://dugi-doc.udg.edu/bitstream/10256/22462/2/license_rdf " >
< dcterms:description > CC-LICENSE </ dcterms:description >
</ rdf:Description >
< rdf:Description about =" https://dugi-doc.udg.edu/bitstream/10256/22462/1/d2ra07227k.pdf " >
< dcterms:description > ORIGINAL </ dcterms:description >
</ rdf:Description >
</ oreatom:triples >
</ atom:entry >
<?xml version="1.0" encoding="UTF-8" ?>
< qdc:qualifieddc schemaLocation =" http://purl.org/dc/elements/1.1/ http://dublincore.org/schemas/xmls/qdc/2006/01/06/dc.xsd http://purl.org/dc/terms/ http://dublincore.org/schemas/xmls/qdc/2006/01/06/dcterms.xsd http://dspace.org/qualifieddc/ http://www.ukoln.ac.uk/metadata/dcmi/xmlschema/qualifieddc.xsd " >
< dc:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ dc:title >
< dc:creator > Riesco-Llach, Gerard </ dc:creator >
< dc:creator > Planas i Grabuleda, Marta </ dc:creator >
< dc:creator > Feliu Soley, Lídia </ dc:creator >
< dc:creator > Joule, John A. </ dc:creator >
< dc:subject > Compostos bioactius -- Síntesi </ dc:subject >
< dc:subject > Bioactive compounds -- Synthesis </ dc:subject >
< dc:subject > Pirazines -- Síntesi </ dc:subject >
< dc:subject > Pyrazines -- Synthesis </ dc:subject >
< dcterms:abstract > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ dcterms:abstract >
< dcterms:dateAccepted > 2023-01-17T14:10:46Z </ dcterms:dateAccepted >
< dcterms:available > 2023-01-17T14:10:46Z </ dcterms:available >
< dcterms:created > 2023-01-17T14:10:46Z </ dcterms:created >
< dcterms:issued > 2023-01-04 </ dcterms:issued >
< dc:type > info:eu-repo/semantics/article </ dc:type >
< dc:identifier > http://hdl.handle.net/10256/22462 </ dc:identifier >
< dc:identifier > https://doi.org/10.1039/D2RA07227K </ dc:identifier >
< dc:identifier > 035933 </ dc:identifier >
< dc:identifier > 2046-2069 </ dc:identifier >
< dc:language > eng </ dc:language >
< dc:relation > Reproducció digital del document publicat a: https://doi.org/10.1039/D2RA07227K </ dc:relation >
< dc:relation > RSC Advances, 2023,vol. 13, p. 1162-1184 </ dc:relation >
< dc:relation > Articles publicats (D-Q) </ dc:relation >
< dc:rights > http://creativecommons.org/licenses/by-nc/4.0/ </ dc:rights >
< dc:rights > info:eu-repo/semantics/openAccess </ dc:rights >
< dc:rights > Attribution-NonCommercial 4.0 International </ dc:rights >
< dc:publisher > Royal Society of Chemistry (RSC) </ dc:publisher >
</ qdc:qualifieddc >
<?xml version="1.0" encoding="UTF-8" ?>
< rdf:RDF schemaLocation =" http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd " >
< ow:Publication about =" oai:dugi-doc.udg.edu:10256/22462 " >
< dc:title > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ dc:title >
< dc:creator > Riesco-Llach, Gerard </ dc:creator >
< dc:creator > Planas i Grabuleda, Marta </ dc:creator >
< dc:creator > Feliu Soley, Lídia </ dc:creator >
< dc:creator > Joule, John A. </ dc:creator >
< dc:subject > Compostos bioactius -- Síntesi </ dc:subject >
< dc:subject > Bioactive compounds -- Synthesis </ dc:subject >
< dc:subject > Pirazines -- Síntesi </ dc:subject >
< dc:subject > Pyrazines -- Synthesis </ dc:subject >
< dc:description > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ dc:description >
< dc:date > 2023-01-17T14:10:46Z </ dc:date >
< dc:date > 2023-01-17T14:10:46Z </ dc:date >
< dc:date > 2023-01-04 </ dc:date >
< dc:type > info:eu-repo/semantics/article </ dc:type >
< dc:identifier > http://hdl.handle.net/10256/22462 </ dc:identifier >
< dc:identifier > https://doi.org/10.1039/D2RA07227K </ dc:identifier >
< dc:identifier > 035933 </ dc:identifier >
< dc:identifier > 2046-2069 </ dc:identifier >
< dc:language > eng </ dc:language >
< dc:relation > Reproducció digital del document publicat a: https://doi.org/10.1039/D2RA07227K </ dc:relation >
< dc:relation > RSC Advances, 2023,vol. 13, p. 1162-1184 </ dc:relation >
< dc:relation > Articles publicats (D-Q) </ dc:relation >
< dc:rights > http://creativecommons.org/licenses/by-nc/4.0/ </ dc:rights >
< dc:rights > info:eu-repo/semantics/openAccess </ dc:rights >
< dc:rights > Attribution-NonCommercial 4.0 International </ dc:rights >
< dc:publisher > Royal Society of Chemistry (RSC) </ dc:publisher >
</ ow:Publication >
</ rdf:RDF >
<?xml version="1.0" encoding="UTF-8" ?>
< metadata schemaLocation =" http://www.lyncode.com/xoai http://www.lyncode.com/xsd/xoai.xsd " >
< element name =" dc " >
< element name =" contributor " >
< element name =" author " >
< element name =" none " >
< field name =" value " > Riesco-Llach, Gerard </ field >
< field name =" value " > Planas i Grabuleda, Marta </ field >
< field name =" value " > Feliu Soley, Lídia </ field >
< field name =" value " > Joule, John A. </ field >
</ element >
</ element >
</ element >
< element name =" date " >
< element name =" accessioned " >
< element name =" none " >
< field name =" value " > 2023-01-17T14:10:46Z </ field >
</ element >
</ element >
< element name =" available " >
< element name =" none " >
< field name =" value " > 2023-01-17T14:10:46Z </ field >
</ element >
</ element >
< element name =" issued " >
< element name =" none " >
< field name =" value " > 2023-01-04 </ field >
</ element >
</ element >
</ element >
< element name =" identifier " >
< element name =" uri " >
< element name =" none " >
< field name =" value " > http://hdl.handle.net/10256/22462 </ field >
</ element >
</ element >
< element name =" doi " >
< element name =" none " >
< field name =" value " > https://doi.org/10.1039/D2RA07227K </ field >
</ element >
</ element >
< element name =" idgrec " >
< element name =" none " >
< field name =" value " > 035933 </ field >
</ element >
</ element >
< element name =" eissn " >
< element name =" none " >
< field name =" value " > 2046-2069 </ field >
</ element >
</ element >
</ element >
< element name =" description " >
< element name =" abstract " >
< element name =" cat " >
< field name =" value " > Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021 </ field >
</ element >
</ element >
< element name =" provenance " >
< element name =" en " >
< field name =" value " > Submitted by Claudia Plana (claudia.plana@udg.edu) on 2023-01-17T14:10:46Z No. of bitstreams: 2 license_rdf: 914 bytes, checksum: 24013099e9e6abb1575dc6ce0855efd5 (MD5) d2ra07227k.pdf: 2762086 bytes, checksum: d7dfebe5a2889455a9d92e394bf1e6f4 (MD5) </ field >
< field name =" value " > Made available in DSpace on 2023-01-17T14:10:46Z (GMT). No. of bitstreams: 2 license_rdf: 914 bytes, checksum: 24013099e9e6abb1575dc6ce0855efd5 (MD5) d2ra07227k.pdf: 2762086 bytes, checksum: d7dfebe5a2889455a9d92e394bf1e6f4 (MD5) Previous issue date: 2023-01-04 </ field >
</ element >
</ element >
< element name =" sponsorship " >
< element name =" cat " >
< field name =" value " > G. R.-L. is recipient of a predoctoral fellowship from the University of Girona (IFUdG2020) </ field >
</ element >
</ element >
</ element >
< element name =" format " >
< element name =" mimetype " >
< element name =" cat " >
< field name =" value " > application/pdf </ field >
</ element >
</ element >
</ element >
< element name =" language " >
< element name =" iso " >
< element name =" cat " >
< field name =" value " > eng </ field >
</ element >
</ element >
</ element >
< element name =" publisher " >
< element name =" cat " >
< field name =" value " > Royal Society of Chemistry (RSC) </ field >
</ element >
</ element >
< element name =" relation " >
< element name =" isformatof " >
< element name =" cat " >
< field name =" value " > Reproducció digital del document publicat a: https://doi.org/10.1039/D2RA07227K </ field >
</ element >
</ element >
< element name =" ispartof " >
< element name =" cat " >
< field name =" value " > RSC Advances, 2023,vol. 13, p. 1162-1184 </ field >
</ element >
</ element >
< element name =" ispartofseries " >
< element name =" cat " >
< field name =" value " > Articles publicats (D-Q) </ field >
</ element >
</ element >
</ element >
< element name =" rights " >
< element name =" * " >
< field name =" value " > Attribution-NonCommercial 4.0 International </ field >
</ element >
< element name =" uri " >
< element name =" * " >
< field name =" value " > http://creativecommons.org/licenses/by-nc/4.0/ </ field >
</ element >
</ element >
< element name =" accessRights " >
< element name =" cat " >
< field name =" value " > info:eu-repo/semantics/openAccess </ field >
</ element >
</ element >
</ element >
< element name =" subject " >
< element name =" cat " >
< field name =" value " > Compostos bioactius -- Síntesi </ field >
< field name =" value " > Bioactive compounds -- Synthesis </ field >
< field name =" value " > Pirazines -- Síntesi </ field >
< field name =" value " > Pyrazines -- Synthesis </ field >
</ element >
</ element >
< element name =" title " >
< element name =" cat " >
< field name =" value " > 2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations </ field >
</ element >
</ element >
< element name =" type " >
< element name =" cat " >
< field name =" value " > info:eu-repo/semantics/article </ field >
</ element >
< element name =" version " >
< element name =" cat " >
< field name =" value " > info:eu-repo/semantics/publishedVersion </ field >
</ element >
</ element >
< element name =" peerreviewed " >
< element name =" cat " >
< field name =" value " > peer-reviewed </ field >
</ element >
</ element >
</ element >
</ element >
< element name =" adm " >
< element name =" sets " >
< element name =" hidden " >
< element name =" cat " >
< field name =" value " > rc1 </ field >
</ element >
</ element >
</ element >
</ element >
< element name =" bundles " >
< element name =" bundle " >
< field name =" name " > LICENSE </ field >
< element name =" bitstreams " >
< element name =" bitstream " >
< field name =" name " > license.txt </ field >
< field name =" originalName " > license.txt </ field >
< field name =" format " > text/plain </ field >
< field name =" size " > 1748 </ field >
< field name =" url " > https://dugi-doc.udg.edu/bitstream/10256/22462/3/license.txt </ field >
< field name =" checksum " > 8a4605be74aa9ea9d79846c1fba20a33 </ field >
< field name =" checksumAlgorithm " > MD5 </ field >
< field name =" sid " > 3 </ field >
</ element >
</ element >
</ element >
< element name =" bundle " >
< field name =" name " > CC-LICENSE </ field >
< element name =" bitstreams " >
< element name =" bitstream " >
< field name =" name " > license_rdf </ field >
< field name =" originalName " > license_rdf </ field >
< field name =" format " > application/rdf+xml; charset=utf-8 </ field >
< field name =" size " > 914 </ field >
< field name =" url " > https://dugi-doc.udg.edu/bitstream/10256/22462/2/license_rdf </ field >
< field name =" checksum " > 24013099e9e6abb1575dc6ce0855efd5 </ field >
< field name =" checksumAlgorithm " > MD5 </ field >
< field name =" sid " > 2 </ field >
</ element >
</ element >
</ element >
< element name =" bundle " >
< field name =" name " > ORIGINAL </ field >
< element name =" bitstreams " >
< element name =" bitstream " >
< field name =" name " > d2ra07227k.pdf </ field >
< field name =" originalName " > d2ra07227k.pdf </ field >
< field name =" format " > application/pdf </ field >
< field name =" size " > 2762086 </ field >
< field name =" url " > https://dugi-doc.udg.edu/bitstream/10256/22462/1/d2ra07227k.pdf </ field >
< field name =" checksum " > d7dfebe5a2889455a9d92e394bf1e6f4 </ field >
< field name =" checksumAlgorithm " > MD5 </ field >
< field name =" sid " > 1 </ field >
</ element >
</ element >
</ element >
</ element >
< element name =" others " >
< field name =" handle " > 10256/22462 </ field >
< field name =" identifier " > oai:dugi-doc.udg.edu:10256/22462 </ field >
< field name =" lastModifyDate " > 2023-01-17 15:10:47.001 </ field >
</ element >
< element name =" repository " >
< field name =" name " > DUGiDocs </ field >
< field name =" mail " > oriol.olive@udg.edu </ field >
</ element >
< element name =" license " >
< field name =" bin " > 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 </ field >
</ element >
</ metadata >